Just as I going to compile a list, lo and behold the internet already had one
Flight 1 is the most prestigious flight number assigned by airlines. It’s used to denote a historic route, or one that an airline regards as their flagship service.
Here are the North American Airports that currently are the origin or destination airport of a Flight 1.
Airline-----Flight Number-Route
Aeromexico-------AM1----Mexico City(MEX) to Madrid(MAD)
Air Canada--------AC1----Toronto(YYZ) to Tokyo(HND)
Air Tahiti Nui------TN1----Los Angeles(LAX) to Papeete(PPT)
AirAsiaX-----------D71----Kuala Lumpur(KUL) to Honolulu(HNL)
Alaska Airlines ----AS1---Washington(DCA) to Seattle(SEA)
American Airlines-AA1----New York(JFK) to Los Angeles(LAX)
ANA----------------NH1---Washington(IAD) to Tokyo(NRT)
British Airways----BA1----London(LHR) to New York(JFK)
China Airlines------CI1---Honolulu(HNL) to Taipei(TPE)
Delta Air Lines-----DL1---London(LHR) to New York(JFK)
El Al----------------LY1----Tel Aviv(TLV) to New York(JFK)
Hawaiian Airlines--HA1---Los Angeles(LAX) to Honolulu(HNL)
Japan Airlines------JL1----San Francisco(SFO) to Tokyo(HAN)
JetBlue Airways----B61---New York(JFK) to Ft Lauderdale(FLL)
Jetstar Airways----JQ1----Melbourne(MEL) to Honolulu(HNL)
Korean Air---------KE1---Seoul(ICN) to Honolulu(HNL)
LOT Polish Airlines-LO1---Warsaw(WAW) to Chicago(ORD)
Singapore Airlines-SQ1---San Francisco(SFO) to Singapore(SIN)
Southwest Airlines-WN1--Dallas(DAL) to Corpus Christi(CRP)
Turkish Airlines-----TK1---Istanbul(IST) to New York(JFK)
United Airlines------UA1---San Francisco(SFO) to Singapore(SIN)
Virgin Atlantic-------VS1--London(LHR) to New York(JFK)
Virgin Australia-----VA1---Sydney(SYD) to Los Angeles(LAX)
WestJet-------------WS1---Calgary(YYC) to London(LGW)
https://www.nomadicnotes.com/flight-1/