Hudson Site Tower, Detroit. 734 feet and 52 stories, though, I'm not sure if the floor count is just the tower or includes the podium levels. Site prep works starts in December:
Not sure how much of a "major" city it is, but Grand Rapids does have a metropolitan area of over 1 million people. It's tallest is 10 Ionia, which will be 418 feet and 40 stories.
__________________ Where the trees are the right height