I found listings for 355 South Grand in most of the CDs between 1911 and 1942. The building also seems to have housed various beauty shops from 1926 onwards. Maybe this info will help anyone who fancies taking on the census cards
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1911: Beatrice Keough, furnished rooms
1915: Beatrice Keough, furnished rooms
1917 Beatrice Keough listed as resident, but not in the furnished rooms section
1918: No listings found
1921: No listings found (Maurice R Walton is listed with apartments at 402 Crocker)
1923: Maurice R Walton, furnished rooms
1926: John D Danton, furnished rooms/Matthaeus (also spelled Matthews) Seeger, beauty parlor/Frances R Parrish, milliner
1927: J D Danton, furnished rooms/Matthew Seeger, beauty parlor
1929: Danton Apartments (John D Danton)/Claire Wacke, beauty shop
1932: John Danton, apartments/Polonia Apartments/Martha Anderson, beauty shop
1936: Ellen Amaker, furnished rooms
1938: Ellen Amacker listed as resident, but not in the furnished rooms section
1939: Amacker Hotel, furnished rooms/Roma Anderson, beauty shop
1942: Amacker Hotel, furnished rooms/Roma Anderson, beauty shop
For some reason, Ellen Amaker's name acquired a "c" between 1936 and 1938. I had a closer look, and found the following listings in the 1936 CD:
Amaker Ellen furn rms 355 S Grand av
Amackher Thos auto park 210 N Los Angeles r354 S Grand av
By the 1939 CD this has changed to:
Amacker Hotel 355 S Grand av
Amacker Thos H (Ellen) auto park 515 W 4th h355 S Grand av
So did Thomas H Amackher marry Ellen Amaker and meet in the middle with their similar surnames? It certainly looks like Thomas moved across South Grand from 354 to 355.