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Originally Posted by yuriandrade
Santiago is within 4:30 flight from 4 megacities (Buenos Aires, São Paulo, Rio de Janeiro and Lima).
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Okay, let's use your random metric of 4.5 hours then.
First of all, one can fly from San Francisco to any populated place in California within that time frame. California has about 40,000,000 people--which is more than twice the entire population of Chile.
Second, one can fly from San Francisco within that timeframe to the following 1M+ metropolitan areas outside of California: Albuquerque, Atlanta, Austin, Calgary, Chicago, Cincinnati, Ciudad Juarez, Cuernavaca, Dallas, Dayton, Denver, Edmonton, El Paso, Guadalajara, Houston, Indianapolis, Kansas City, Las Vegas, Mexico City, Milwaukee, Minneapolis, Monterrey, Nashville, New Orleans, Oklahoma City, Phoenix, Portland, Puebla, Saint Louis, Salt Lake City, San Antonio, Seattle, Tijuana, Toluca, Tucson, and Vancouver (close but no cigar: Columbus at 4 hours, 34 minutes; Detroit at 4 hours, 37 minutes).
So that's 36 such metros, in addition to California's 1M+ metros of Los Angeles, San Diego, Sacramento, and Fresno.
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Within this radius there are Cordoba, Rosario, Mendoza (ARGENTINA); Assuncion (PARAGUAY), Montevideo (URUGUAY), Porto Alegre, Florianópolis, Curitiba, Londrina, at least 5 metro areas inside São Paulo macrometropolitan area, Ribeirão Preto, Belo Horizonte, Campo Grande (BRAZIL), Santa Cruz de la Sierra, La Paz (BOLIVIA); Arequipa (PERU). 20 cities aside the 4 aforementioned megacities.
And considering +500,000 urban areas, in Brazil alone you have at least extra 10-12 more cities inside this radius.
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Considering how many 1M+ metros one can fly to in 4.5 hours from San Francisco, I'm not even bothering with 500K metros. If the metric is 1M+ metropolitan areas within four and a half hours' travel time, the data shows Santiago is more geographically isolated than San Francisco.