You're taking your company to Little Italy smack in the middle of the Italian Week festival. Not sure if you were aware of that, but nonetheless it promises both great fun and challenges. Crowds should be heavy on a Friday night, especially if the weather holds, so you may not have a lot of choice as to where you eat.
Obviously you can get great Italian food in Little Italy, but there are many other choices, so it really depends on what you're craving. There's Thai, Korean, Vietnamese, Greek (a new place called EVOO), Japanese, Turkish, a variety of pubs, etc.
Because the options are numerous and varied, I'd suggest you browse this guide to get yourself familiar with the area offerings:
http://www.urbanspoon.com/n/250/4626...ly-restaurants