I've searched NLA, and can't find any previous mentions of property developer Isaac Newton Van Nuys' house at 1445 West 6th Street. USC date this picture at circa 1904.
USC Digital Library
I found the address and the wider view below in an article titled
Van Nuys--But He Didn't Live There.
oldhomesoflosangeles.blogspot.com
The good news is that the house was subsequently moved to Windsor Square, and can still be found on the corner of Fourth Street and Lorraine Boulevard. A site called
www.perrymasontvseries.com has screengrabs of the house appearing in two episodes of the show.
IMDb also says it was used in an episode of 'Murder, She Wrote', the 2003 remake of 'Cheaper by the Dozen', and an episode of 'Scarecrow and Mrs. King' (see
Moxie's SMK Forum post
here).
Google Maps