Cairo, Illinois has had a rather checkered past, and over the last 100 years has gone from over 15,000 residents to a bit over 2,000.
More info:
https://en.wikipedia.org/wiki/Cairo,_Illinois
Here's a link to some Flickr pics from Bruce Wicks. Some nice buildings, but also plenty of abandoned grit:
https://www.flickr.com/photos/touris...57624296474196