Quote:
Originally Posted by iheartthed
Santo Domingo was possibly the largest city in North America in the period between the Columbus expedition until the Industrial Revolution. Mexico City was the only other in North America that would've rivaled it in population during that period.
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I believe Lima was very big/important during the colonial period as well. If I'm not mistaken the first university in Americas was founded there. Not sure how it compares with those two population wise though.